Two limbic encephalitis cases with potassium channel antibodies

Background: Autoimmune limbic encephalitis is presented with the involvement of limbic structures. It is a diff erent entity rather than a component of paraneoplastic limbic encephalitis. In recent years, limbic encephalitis cases with immune-mediated voltage gated potassium channel antibody that respond to immunotherapies have been described. Case reports: We present two male patients aged 45 and 59. Both patients had elevated levels of potassium channel antibodies and presented with short-term memory impairment, psychiatric symptoms, and the fi rst case had epileptic seizures additionally. Th eir radiological fi ndings were typical for limbic encephalitis and both responded to immunotherapy. Conclusion: In this report, we emphasize that limbic encephalitis should be suspected in patients with subacute cognitive impairment, psychiatric symptoms and epilepsy resistant to therapy. Since the disorder is mostly reversible, early diagnosis and treatment is important.